The history of testosterone replacement therapy is a long, storied, and interesting one. There has been quite a long road to get from there to Testogel, and it all starts considerably before UK Meds was even founded. Testosterone replacement therapy was originally called “organotherapy”, dating from old folklore. Organotherapy was essentially the practice of treating like with like, or treating the problem with the problem, as it were. There were four key pieces of research, and the researchers that discovered them, that led to the eventual creation of testosterone replacement theory, and it all started in 1849 with a man named Arnold Berthauld.
Arnold Berthauld was a zoo curator in 1849, and he was fascinated with animals. The zoo that he curated was in Goettingen, Germany. He normally observed the roosters, as they fascinated him. Specifically, the castrated ones fascinated him. He noticed that after the roosters underwent the process of castration, they stopped fighting, crowing and mating. In addition to that, the roosters’ combs, the red crest on the top of their heads, began to shrink. However, when the roosters’ testicles were surgically re-attached, their behaviour returned to normal and their combs grew back to their regular size. Berthauld thought about it, and he later said that it was his theory that the blood is affected by the testicles and the blood affects the rest of the animal. In doing so, Berthauld inadvertently discovered the very first hormone, testosterone, and he invented the field of endocrinology.
Charles E. Brown-Séquard
The next explosion in the field of endocrinology came at the end of the 19th century with the announcements of Charles E. Brown-Séquard. Brown-Séquard was a very esteemed scientist, and he also had membership in several prestigious academic institutions. He published an essay that detailed Brown-Séquard’s experiments that he conducted on himself. He injected himself daily with one millilitre of a mixture of testicular blood, semen, and juice that Brown-Séquard took daily from dog and guinea pig testicles.
After a period of twenty days, he reported some of the changes that he thought were in effect. He said that he had regained the strength and vitality of his youth. His endurance, measured by his ability to conduct experiments for multiple hours at a time, was also greatly increased. After he ate dinner, he reported that he was able to write a detailed paper on a complex subject with some ease. After doing some tests on his extremities, he discovered that the strength of his limbs had increased. Using a dynamometer, he gauged his newfound strength to be about six to seven kilograms increased. Keep in mind that, at the time, Brown-Séquard was likely to be in the second half of his life. Finally, Brown-Séquard’s ability to urinate and defecate effectively also received a marked increase, according to him.
Of course, the modern medical community now considers those placebo effects, but Brown-Séquard was able to market it effectively enough to create an incredibly large demand for what he was selling. Probably the most important discovery that debunked Brown-Séquard’s products was the fact that it had no androgen within it. However, the acclaim and popularity that he received were enough to spur more research within the field of endocrinology.
- Frank Lydston
Standing backwards on the shoulders of the previously mentioned scientists, G. Frank Lydston, living from 1858 – 1923, endeavoured to try a misguided attempt to engage in a primitive form of testicular replacement theory: transplantation. Lydston and his contemporaries attempted to increase the testosterone levels of men at the time by removing and transplanting the testicles of animals (such as monkeys) onto humans. Apparently, this resulted in more than a few happy customers. However, after a time, this practice was eventually disallowed, seeing as how it involved animal cruelty and a host of other issues.
One of the more successful experiments that Lydston and his contemporaries performed, however, was human to human transplantation. Sometimes Lydston would get willing donors, and other times he received donations from prisons. Those prisons would execute prisoners and then donate their testicles to Lydston to use in his transplants. This method was unorthodox, it worked surprisingly well. One of his contemporaries reported at least twenty cases of rejuvenation from patients who received this treatment.
Carl Heller and Gordon Myers
The fourth and final piece of the puzzle came in 1944, a little while past when testosterone was first successfully synthesized. In their paper, Heller and Myers were able to prove that the symptoms of ageing for old men could be attributed to hypogonadism, which helped to prove the link between testosterone and the health of the human body.
Those symptoms included depression, easy fatigability, lack of memory performance, and lower sexual appetite. Obviously, they could not easily measure how much testosterone or semen the men had that they were attempting to test. Therefore, Heller and Myers created the diagnosis of ‘male climacteric.’ By dissecting the gonads of dead men, they were able to point out the difference in the health of men who were castrated and men who had their testicles. They were also able to prove that men who suffered from male climacteric were able to improve their condition through injection of testosterone.
And then the present arrives. Ever since Heller and Myers, testosterone replacement therapy was done by injecting testosterone directly into the patient. Although this approach is slightly damaging to the patient, that was all that was available at the time. Now, however, that has changed. Once testosterone gel was invented, the game changed. Companies like UK Meds were able to develop and improve upon gel-based treatment policies. Rather than relying on the somewhat damaging and painful method of injection, men who suffer from low testosterone, whether from hypogonadism or simply old age, are able to help their condition without pain. That is one of the reasons why Testogel was created, in order to continue the long tradition of innovation and creativity that defines the field of endocrinology.